Negative fateful life events in midlife and advanced predicted brain aging
نویسندگان
چکیده
منابع مشابه
Brain aging and midlife tofu consumption.
OBJECTIVE To examine associations of midlife tofu consumption with brain function and structural changes in late life. METHODS The design utilized surviving participants of a longitudinal study established in 1965 for research on heart disease, stroke, and cancer. Information on consumption of selected foods was available from standardized interviews conducted 1965-1967 and 1971-1974. A 4-lev...
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The effects of aging were traditionally thought to be immutable, particularly evident in the loss of plasticity and cognitive abilities occurring in the aged central nervous system (CNS). However, it is becoming increasingly apparent that extrinsic systemic manipulations such as exercise, caloric restriction, and changing blood composition by heterochronic parabiosis or young plasma administrat...
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متن کاملEarly-life events. Effects on aging.
During the last two decades, a considerable body of evidence has emerged showing that circumstances during the fetal period and childhood may have lifelong programming effects on different body functions with a considerable impact on disease susceptibility. From a medical point of view, these long-term effects are today referred to as the Developmental Origins of Health and Disease (DOHaD) conc...
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BACKGROUND AND PURPOSE Although white matter lesions (WMLs) on brain MRI in older persons are common, the mechanisms are unclear. Besides the associations with advanced age and high blood pressure (BP), variability in systolic BP (SBP) and the resulting changes in blood flow to the deep arteries of the brain may be contributing factors. METHODS Japanese-American men in Hawaii have participate...
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ژورنال
عنوان ژورنال: Neurobiology of Aging
سال: 2018
ISSN: 0197-4580
DOI: 10.1016/j.neurobiolaging.2018.03.004